Williamson Back Pain Related to Inflammation Reduced with Melatonin
Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to damaging stimuli (injury, pathogens, metabolic stress – a disc herniation pushing on a nerve!) as it attempts to restore itself to normal before the harm was achieved. Apple Country Chiropractic is never shocked at what the body can do! Apple Country Chiropractic sees its Williamson chiropractic care as the body’s partner in healing especially when there is spine pain. Chiropractic care uses many tools like spinal manipulation, exercise, and nutrition to take care of the body. Melatonin is one nutritional tool that is showing value in its ability to interrupt the inflammatory process related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are linked to intervertebral disc degeneration. (1) IL-1 β actually promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body regulates itself down to the cellular level via autophagy, the natural process via which the body’s cells clear out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin boosted autophagy and lessened the degradation of the disc’s extracellular matrix (technically indicated by a decline in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The final conclusion was that melatonin prevents intervertebral disc degeneration by stimulating autophagy. (3) Wow. Apple Country Chiropractic is encouraged by this research to see just how well melatonin can perform for Williamson back pain linked to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is such a common malady seen at Apple Country Chiropractic making positive news like this quite rousing. A new study stated that melatonin could modulate the extracellular matrix of the disc remodeling process started by IL-1 β. Additionally, melatonin decreased the inflammatory cell collection and decreased the release of associated inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery that melatonin disrupted the IL-1B feedback loop, researchers suggested that melatonin may contribute to the restoration process of intervertebral discs after damage was already present. (1) Apple Country Chiropractic continues following the new research on the role inflammation has in Williamson disc degeneration and melatonin’s role in reducing it.
INFLAMMATION AND MELATONIN
The importance of melatonin in assisting to slow or stop painful conditions due to inflammation is increasing. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other mechanisms is quite suitable. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by hindering the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland produces melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) processes. (1) Melatonin’s specific effect on inflammation and disc degeneration is most attention-getting to Apple Country Chiropractic and our Williamson back pain patients.
CONTACT Apple Country Chiropractic
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management addresses disc degeneration for relief of chronic low back pain in her patient.
Schedule your Williamson chiropractic appointment with Apple Country Chiropractic soon. We can discuss how inflammation affects your back pain and how melatonin may help with the related disc degeneration.
